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NON-CARBOXYLIC ANALOGUES OF ARYLPROPIONIC ACIDS: SYNTHESIS,
ANTI-INFLAMMATORY ACTIVITY AND ULCEROGENIC POTENTIAL |
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Abstract:
Two series of 1,2,4-triazoles
and 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles derived from three
selected arylpropionic acids namely, ibuprofen, flurbiprofen and
naproxen, were synthesized and evaluated for anti-inflammatory
activity and ulcerogenic potential. All the tested compounds
exhibited anti-inflammatory activity comparable to that of
hydrocortisone. Compared to ibuprofen however, all the tested
compounds displayed more potent anti-inflammatory activity.
Compounds tested for ulcerogenecity showed no or minimal ulcerogenic
effect compared to indomethacin.
pdf
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